Gradius is a planet in an unspecified region of space. The local Gradians were the ones who invented and constructed the infamous Vic Viper ships, although the first one cost the planet $60 trillion Gradian dollars, practically bankrupting the planet. Since then, however, a full fleet of Vic Vipers now exist.
- Mysterious pilot of Vic Viper T-301
- David Burton, pilot of the Vixen and descendant of James Burton.
- Doctor Venom, inventor of the Vic Viper and Metalion ships.
- Eddie Evans, Vic Viper pilot; may have been born on Latis.
- Iggy Rock, pilot of the Sabel Tiger and savior of planet Latis.
- James Burton, original Vic Viper and Metalion pilot.
- LARS XVII, 17th emperor of the planet Gradius.
- Lieutenant Dan, Vic Viper pilot.
- Van Landroth Frehley, head of Gradius' Imperial Space Archaeology Institute.
- Zowie Scott, pilot of the Thrasher and savior of planet Latis.