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The class was used primarily as a dispensary, ferrying supplies between large bases and the many RMSUs scattered around the galaxy. The frigates also acted as mobile hospital units themselves, making them quite expensive for ships their size, prohibitively so to some. Despite this, the ravages of the Clone Wars forced the Galactic Republic to order more ships.
The class was often used alongside Pelta-class frigates, which were more heavily armed and served as their escorts. Despite this, the Republic generally banked on the MedStar-class ships being left alone due to their status as hospital ships.
Later on, MedStar-class frigates served in the Galactic Empire.